Abstract
Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.
MeSH terms
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Drug Design
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Dual-Specificity Phosphatases
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Mitogen-Activated Protein Kinase Phosphatases
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Molecular Structure
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Protein Phosphatase 1
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Protein Tyrosine Phosphatases / antagonists & inhibitors*
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Rhodanine / analogs & derivatives
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Rhodanine / chemical synthesis
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Rhodanine / pharmacology*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Rhodanine
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Mitogen-Activated Protein Kinase Phosphatases
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Protein Phosphatase 1
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DUSP22 protein, human
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Dual-Specificity Phosphatases
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Protein Tyrosine Phosphatases